The human body consists of trillions of cells, but a mutation in one of them can cause cancer.
This example demonstrates that biology is not a process driven by averages and highlights the importance of single cell-level studies. The last years have seen a rapid expansion of the field of single-cell genomics, which has enabled paradigm shifts in many fields of biological sciences, ranging from evolutionary biology over stem cell biology to cancer research.
The ISCO conference is co-organized by leading centres for genomic and biomedical research in Berlin and Barcelona and brings together young single cell researchers from different disciplines to enable scientific exchange and foster new international collaborations. Topics are innovations in single-cell and spatially-resolved technologies, new computational approaches and applications in the medical arena. ISCO puts special emphasis on providing networking opportunities for PhD students and postdocs, with a large number of talks from selected abstract, a poster session and a proper party.
This year’s 3rd edition of ISCO is back in Barcelona.
Venue
Dates
May 27, 2024, 9:00 AM - May 28, 2024, 6:00 PM
Keynote Speakers
John Marioni
Genentech-Roche, EMBL-EBI, CRUK Cambridge Institute
UK
Theodore Alexandrov
EMBL, BioInnovation Institute
Germany
Invited Speakers
Caleb Lareau
Sloan Kettering Institute
USA
Gioele La Manno
École Polytechnique Fédérale de Lausanne
Switzerland
Linde Miles
Cincinnati Children's
USA
Mor Nitzan
The Hebrew University of Jerusalem
Israel
Sydney Shaffer
University of Pennsylvania
USA
Yonatan Stelzer
Weizmann Institute of Science
Israel
Flashtalk
Laura Jiménez-Gracia
Centro Nacional de Análisis Genómico
Spain
Yanay Rosen
Stanford University
USA
Michael Scherer
Centre for Genomic Regulation
Spain
Aitor González
Josep Carreras Leukaemia Research Institute
Spain
James Cotterell
EMBL Barcelona
Spain
TBC
TBC
TBC
Chiara Reggio
Scale Biosciences
Global Distribution Manager
Llorenç Solé-Boldo
MDC-BIMSB/BIH/Charité
Germany
Magdalena Pajonk
University Hospital Heidelberg/DKFZ
Germany
Viola Hollek
Charité
Germany
Indranil Singh
IRB Barcelona
Spain
Jeroen Aerts
Deep Cell
Market Development Manager EMEA
Martina Macino
MDC/Berlin Institute of Medical Systems Biology
Germany
Maria Sopena-Rios
Barcelona Supercomputing Center
Spain
Agnieszka Ciesielska
10X Genomics
Science & Technology Advisor
Lena Nitsch
Berlin Institute of Health at Charité
Germany
Sara Lobato-Moreno
European Molecular Biology Laboratory
Germany
Yu-Hsin Hsieh
Berlin Institute of Medical Systems Biology
Germany
Rory Maizels
The Francis Crick Institute
UK
Program
Day 1 - May 27 2024
08:30 - 09:30
Arrival and Registration (Coffee and tea served)
09:30
Opening Remarks
Session 1: Computational biology | Chair: Elisabetta Mereu
09:40
Gioele La Manno (École Polytechnique Fédérale de Lausanne, Switzerland)
"No flight of fancy: Manifold-Constrained Statistical Inference on Cellular Process Dynamics"
10:15
Yanay Rosen (Stanford University, USA)
Selected talk "Uncovering Structure Across the Universal Landscape of Cell Biology Spanning Species, Cell Types and Cell States"
10:35
Michael Scherer (Centre for Genomic Regulation , Spain)
Selected talk "DNA methylation jointly encodes clonal identity and cell state in single cells"
10:55
Aitor González (Josep Carreras Leukaemia Research Institute, Spain)
Selected talk "Integrative Analysis of Single-Cell Datasets Reveals Insights into Human Pancreatic Function, Renewal, and Regeneration"
11:15
Coffee Break
Session 2: Hematopoiesis | Chair: Alejo Rodríguez-Fraticelli
11:45
Linde Miles (Cincinnati Children's, USA)
"Single cell analysis of clonal evolution in acute myeloid leukemia (AML)"
12:20
Indranil Singh (IRB Barcelona, Spain)
Selected talk "Deciphering Cellular Destiny: Pivotal Role of Stem Cell States' in Shaping Responses to Preleukemic Mutations"
12:40
Lena Nitsch (Berlin Institute of Health at Charité, Germany)
Selected talk "Single-cell resolved longitudinal clonal dynamics in human hematopoiesis and regeneration"
13:00
Chiara Reggio (Scale Biosciences, Global Distribution Manager)
Sponsor talk "Welcome to single-cell genomics at scale"
13:15
Lunch
Session 3: Cancer | Chair: Ashley Sanders
14:30
Sydney Shaffer (University of Pennsylvania, USA)
"Tracking plasticity and cancer evolution in human samples"
15:05
Viola Hollek (Charité, Germany)
Selected talk "Deciphering Oncogenic Signatures in Colorectal Cancer Through Single-Cell Multi-Omics"
15:25
Llorenç Solé-Boldo (MDC-BIMSB/BIH/Charité, Germany)
Selected talk "Bone marrow breakout lesions act as key sites for tumor-immune cell diversification and exhaustion in multiple myeloma"
15:45
Magdalena Pajonk (University Hospital Heidelberg/DKFZ, Germany)
Selected talk "Single-cell metabolic multiomics to identify vulnerabilities in acute myeloid leukemia stem cells"
16:05
Coffee Break
16:30
John Marioni (Genentech-Roche, EMBL-EBI, CRUK Cambridge Institute, UK)
"Moving Beyond Atlases"
17:30
Poster Session
20:00
Dinner and Party
Day 2 - May 28 2024
Session 4: Development | Chair: Stefanie Grosswendt
10:00
Yonatan Stelzer (Weizmann Institute of Science, Israel)
"Toward a canonical spatiotemporal model of early mammalian development"
10:35
James Cotterell (EMBL Barcelona, Spain)
Selected talk "Cell 3D Positioning by Optical encoding (C3PO) and its application to spatial transcriptomics"
10:55
Rory Maizels (The Francis Crick Institute, UK)
Selected talk "Modelling developmental gene regulation from time-resolved single-cell transcriptomics"
11:15
Jeroen Aerts (Deep Cell, Market Development Manager EMEA)
Sponsor talk "Expanding the single-cell omics toolkit with label-free, AI-driven single-cell morphology analysis using REM-I"
11:30
Coffee Break
Session 5: Genomics | Chair: Leif S. Ludwig
12:00
Mor Nitzan (The Hebrew University of Jerusalem, Israel)
"Learning from the information gaps: inference of multicellular organization"
12:35
Yu-Hsin Hsieh (Berlin Institute of Medical Systems Biology, Germany)
Selected talk "Single-cell resolved immune and mitochondrial DNA mutational landscapes of human mitochondrial disorders"
12:55
Martina Macino (MDC/Berlin Institute of Medical Systems Biology, Germany)
Selected talk "DeCRYPTing the somatic mutational landscape in inflammatory bowel disease"
13:15
Lunch
Session 6: Immunology | Chair: Simon Haas
14:30
Caleb Lareau (Sloan Kettering Institute, USA)
"Viral latency and reactivation at single cell resolution"
15:05
Laura Jiménez-Gracia (Centro Nacional de Análisis Genómico, Spain)
Selected talk "Interpretable Inflammation Landscape of Circulating Immune cells"
15:25
Maria Sopena-Rios (Barcelona Supercomputing Center, Spain)
Selected talk "Single-cell atlas of the aging circulating immune system"
15:45
Sara Lobato-Moreno (European Molecular Biology Laboratory, Germany)
Selected talk "Leveraging Single-Cell Ultra-High Throughput Multiome sequencing (SUMseq) to investigate molecular mechanisms governing the innate immune inflammatory response"
16:05
Agnieszka Ciesielska (10X Genomics, Science & Technology Advisor)
Sponsor talk "Discover the complexity of immune system with single cell resolution"
16:20
Coffee Break
16:45
Theodore Alexandrov (EMBL, BioInnovation Institute, Germany)
"Spatial single-cell metabolomics: a powerful technology for revealing metabolic states of cells"
17:45
Closing Remarks
Organizers
Organizers
Lars Velten
Single Cell and Synthetic Genomics of Blood Formation Group Leader
Centre for Genomic Regulation (CRG)
Elisabetta Mereu
Cellular Systems Genomics Group Leader
Josep Carreras Leukaemia Research Institute (JCI)
Alejo Rodríguez-Fraticelli
Quantitative Stem Cell Dynamics Group Leader
Institute for Research in Biomedicine (IRB)
Co-Organizers
Stefanie Grosswendt
From Cell States to Function Group Leader
Berlin Institute of Health at Charité (BIH), Max Delbrück Center for Molecular Medicine (MDC)
Simon Haas
Systems Hematology, Stem Cells & Precision Medicine Group Leader
Berlin Institute of Health at Charité (BIH), Max Delbrück Center for Molecular Medicine (MDC)
Leif S. Ludwig
Stem Cell Dynamics and Mitochondrial Genomics Group Leader
Berlin Institute of Health at Charité (BIH), Max Delbrück Center for Molecular Medicine (MDC)
Ashley Sanders
Genome Instability and Somatic Mosaicism Group Leader
Berlin Institute of Health at Charité (BIH), Max Delbrück Center for Molecular Medicine (MDC)
Supported by
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